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Ivermectin (Iverhelm) treatment is a ”real killer of parasites”

Ivermectin for sale online price vet pharmacy

Ivermectin (Iverhelm)

Characteristics of the substance Ivermectin
Refers to avermectins.

Pharmacology
Pharmacological action – local anti-inflammatory.
Pharmacodynamics

It has an anti-inflammatory effect by suppressing the production of inflammatory cytokines induced by lipopolysaccharides. The anti-inflammatory properties of ivermectin have been observed in animal models of skin inflammatory processes. Ivermectin also causes the death of parasites, mainly through selective binding and high affinity for glutamate-regulated chlorine channels found in the nerve and muscle cells of invertebrates. The mechanism of action of ivermectin in the treatment of inflammatory skin lesions in rosacea is not fully understood, but it may be associated with both anti-inflammatory effects and the ability to cause the death of Demodex mites, which, in turn, can be a factor causing skin inflammation.

Pharmacokinetics

Suction. The absorption of ivermectin was assessed in a clinical study involving adult patients with severe papulopustular rosacea, using the maximum tolerated dose. In equilibrium (after 2 weeks of treatment), the highest mean (± standard deviation) plasma concentrations of ivermectin were observed within (10 ± 8) h after application (Cmax – (2.1 ± 1) ng / ml, range – 0 , 7-4 ng / ml), and the highest mean (± standard deviation) AUC0-24 was (36 ± 16) ng · h / ml, range – 14-75 ng · h / ml). Systemic exposure to ivermectin reached a plateau by the end of the second week of treatment under steady state conditions. With longer treatment in phase III studies, the systemic exposure to ivermectin remained the same as after 2 weeks of treatment. Under Css conditions, the levels of systemic exposure of ivermectin (AUC0-24 (36 ± 16) ng · h / ml) were lower than after a single oral intake of 6 mg ivermectin in healthy volunteers (AUC0-24 (134 ± 66) ng · h / ml) …

Distribution. An in vitro study has shown that the binding of ivermectin to blood plasma proteins (mainly albumin) is more than 99%. No significant binding of ivermectin to erythrocytes was observed.

Metabolism. In in vitro studies using human liver microsomes and recombinant CYP450 enzymes, it has been noted that ivermectin is metabolized primarily by CYP3A4.

In vitro studies have shown that ivermectin does not inhibit the isoenzymes CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP4A11 or CYP2E1. Ivermectin does not induce the expression of isoenzymes CYP1A2, CYP2B6, CYP2C9 or CYP3A4) in cultured human hepatocytes. The two main metabolites of ivermectin (3′-O-demethylivermectin and 4a-hydroxyivermectin) were identified in a clinical pharmacokinetic study using the maximum allowable dose of this agent and were studied in phase II clinical trials. Like the parent compound, the metabolites reached equilibrium by the end of the second weeks of treatment, no signs of accumulation were observed in the period up to 12 weeks In addition, the systemic exposure of metabolites (assessed using Cmax and AUC), obtained at steady state, was much lower than for ivermectin after oral administration.

Excretion. The final T1 / 2 averaged 6 days (approximately 145 hours, range 92-238 hours) in patients who applied ivermectin to the skin 1 time per day for 28 days in a clinical pharmacokinetic study using the maximum allowable dose. Excretion from the body depends on the degree of absorption after topical application. The pharmacokinetics of ivermectin have not been studied in patients with impaired liver and kidney function.

Application of the substance Ivermectin
Inflammatory skin lesions in rosacea (papulopustular form) in adult patients.

Contraindications
Hypersensitivity; pregnancy; period of breastfeeding; age up to 18 years (safety and efficacy for this age category has not been studied).

Restrictions on use
Liver dysfunction.

Application during pregnancy and lactation
Data on the use of ivermectin in pregnant women are limited. Reproductive toxicity studies when taking ivermectin orally have shown that it has teratogenic potential in rats and rabbits, however, due to the low systemic exposure when applied externally at the recommended dosage, the risk of fetotoxicity in humans is low. The use of ivermectin during pregnancy is contraindicated.

After oral administration, low concentrations of ivermectin are excreted into breast milk. When applied topically, the release of ivermectin into breast milk has not been studied. Pharmacokinetic and toxicological data from animal studies also indicate the excretion of ivermectin in breast milk. The risk to the nursing infant cannot be excluded. If necessary, the use of ivermectin should stop breastfeeding.

Side effects of the substance Ivermectin


The most common adverse reactions, such as burning sensation, skin irritation, itching and dry skin, were noted in less than 1% of patients treated with ivermectin in clinical trials.

On the part of the skin and subcutaneous tissues: often (≥1 / 10) – burning sensation of the skin; infrequently (≥1 / 1000, <1/100) – skin irritation, itching, dry skin; frequency unknown – contact dermatitis, allergic reactions.

Typically, these reactions are mild to moderate and usually diminish with continued therapy.

There were no significant differences in the safety profile among patients aged 18 to 65 years and older.

Interaction
Studies on the interaction of ivermectin with other drugs have not been conducted. Concomitant use with other agents for external and systemic use for the treatment of rosacea has not been studied. Caution should be exercised when used simultaneously with strong inhibitors of CYP3A4, since the concentration of ivermectin in the blood plasma can increase significantly.

Overdose
There have been no reported cases of ivermectin overdose.

Symptoms: In case of accidental or significant exposure of a person to unknown amounts of veterinary forms of ivermectin (ingestion, inhalation, parenteral administration or contact with the body surface), skin rash, facial edema, eyelid edema, headache, dizziness, asthenia, nausea, vomiting, etc. diarrhea. Other reported adverse reactions include seizures, ataxia, shortness of breath, abdominal pain, paresthesia, urticaria, and contact dermatitis.

Treatment: in case of accidental ingestion, symptomatic therapy is carried out, including parenteral administration of fluids and electrolytes, respiratory support (providing oxygen and, if necessary, mechanical ventilation) and vasopressors (in the presence of a pronounced decrease in blood pressure). To prevent the absorption of ingested ivermectin, provoking vomiting and / or urgent gastric lavage followed by the use of laxatives and other measures to eliminate intoxication may be indicated.

Route of administration
Outwardly.

Precautions for the substance Ivermectin
The components of the finished dosage form of ivermectin can cause local skin reactions (eg contact dermatitis), allergic reactions (including delayed-type reactions), skin irritation.

Wash your hands after use.

After drying, you can apply cosmetics.

Influence on the ability to drive vehicles and work with mechanisms. Ivermectin does not affect or slightly affects the ability to drive vehicles and operate machinery.

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Parasites in Fish ? Bendazole (Fenbendazole) ? Panacur

Parasites in Fish

Most of the drugs listed below are anthelmintic (antihelminthic) drugs. These are chemical preparations that effectively destroy various parasitic helminths (“worms”). With regard to fish parasites, this group includes trematodes, nematodes and cestodes (tapeworms). These medicines are given to the fish by mouth with food, although some are also effective in the form of baths. Anthelmintics used for bath treatments have been shown to be effective against non-helminth ectoparasites such as Argulus or Argulus carp lice. If the dosage for a specific drug is not listed, you should consult your veterinarian.

Many of the anthelmintic drugs used to treat fish are also used in humans, so in some countries they can only be obtained through a veterinarian. Other such agents, for example trichlorfon, are organophosphorus compounds. These are extremely toxic chemicals, and their sale is highly regulated.

It is important to remember that the life cycle of ectoparasites is quite complex and includes many stages. Some stages are resistant to chemicals, others are more vulnerable. Since resistant stages can remain viable for a long time, re-treatment is often necessary to completely eradicate the parasites.

In addition to the chemicals listed below, there are a number of specialty aquarium medicines on the market for some of the larger ectoparasites. They should be used in accordance with the manufacturer’s instructions. It is very important to follow through with the recommended course of treatment. Allow enough time for the eggs or cysts that are resistant to chemicals to hatch into larvae.

Bendazole Fenbendazole (Panacur)


Fenbendazole is used primarily to treat worms in horses. In addition, it is useful in the fight against fish nematodes such as Camallanus. It can be purchased as an equine anthelmintic. In the aquarium hobby, this medicine is used as a powder or granule, not a dough. A three-week course of treatment is carried out by the method of long baths with a dose of 2 – 3 mg/liter, and on the 7th and 14th days, the procedure is repeated.

Fenbendazole (PANACUR) aquarium dosage

Also be aware that fenbendazole seems to soak into the porous live rock and be absorbed indefinitely. I know one hobbyist who transferred a small piece of live rock that had been treated with fenbendazole (Panacur) months earlier into a reef tank, where it killed the resident starfish and Astrea snails. So enough of the medication may be retained within treated live rock to impact sensitive animals months after the fenbendazole was administered. Don’t treat live rock intended for reef systems with fenbendazole (Panacur)!

At the lower dosage recommended for nursery tanks (1/16 tsp. Per 10 gallons), fenbendazole normally does not harm cleaner shrimp and decorative shrimp. With the exception of Astrids (Astrea), Coit and Worden have found it does not usually affect the types of snails typically used as cleanup crews (e.g., Nassarius, Ceriths, and Nerites). It will kill starfish but copepods, hermit crabs, and shrimp are normally not affected.

Macroalgae such as the feathery or long-bladed varieties of Caulerpa or Hawaiian Ogo (Gracilaria) are not harmed by exposure to fenbendazole at even triple the normal dose. In fact, if you will be using Caulerpa in your nursery tanks to provide hitching posts for the fry and serve as a form of natural filtration, it’s a very wise precaution indeed to treat them with a regimen of fenbendazole beforehand.

fenbendazole panacur suspension safe guard dog pharmacyFenbendazole 10% fish bendazole Liquid SUSPENSION PANACUR

So fenbendazole (FBZ) or Panacur is primarily useful for ridding bare-bottomed nursery tanks and dwarf seahorses setups of hydroids and Aiptasia anemones, ridding Caulerpa and other macroalge of hydroids or Aiptasia before its goes into the aquarium, and cleansing live rock of bristle worms, hydroids, and Aiptasia rock anemones before it is introduced to the aquarium.  If you are serious about raising seahorse fry, fenbendazole is must-have med for keeping your nurseries hydroid free.

It can also be used to eradicate bristle worms, hydroids, an Aiptasia from an established aquarium if it does not house sensitive animals such as live corals and gorgonians, starfish, Astrea snails, or tubeworms and other desirable worms that may be harmed by FBZ, providing you monitor the ammonia levels closely and are prepared to deal with the ammonia spike that may result from the sudden death of the worm population.

Caution: For aquarium and ornamental fish only. not for human use. keep out of the reach of children. keep the container tightly closed and in a cool dry place. not to be given to fish intended for food use.

 
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Albendazole – the most reliable remedy for worms

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Often parasitic worms can infect cats and dogs that eat raw fish, meat, food from a dustbin, and other trash. Animals that spend a lot of time on the streets are also likely to become infected with worms. All pet owners know. “What do I do now?” You can ask. Our shop offers several remedies to treat worm. Albendazole is precisely the main exit to the drug. Let’s see what it is, and why Albendazole is the first choice.

brief information

Albendazole is a drug used for treatment of helminth. It is useful for giardiasis, tricuriasis, filariasis, and ascariasis and other diseases that are caused by parasites. Albendazole was developed in 1975 and is on the list of essential medicines of the World Health Organization. The medicament is intended for oral administration.

How they are infected

German shepherd puppies slightly behind in growth. The body was thin, his head looked too big. But the owner was not worried – the mother of the puppies spent the entire pregnancy in the outdoors, walking a lot, so why be weak? The owner knew I had to give anthelmintics, but as often happens – lost in other concerns. The owner remembered deworming a week before vaccination. She bought suspensions for puppies and tablets by her mother in veterinary pharmacy. Each received a portion of the morning before lunch. And in the evening one of the puppies began to vomit, only to be followed shortly by the second.Something yellow-white long was wiggling into a puddle on the floor. The owner was horrified.

It is unlikely that a pet owner who want to discover something like that . For some reason, everyone thinks it will not affect. This kind of self-complacency is both irrational and dangerous. There are about ten roundworms (nematodes), which affects our cats and dogs. Many of them are very widespread in our country. The best known of all are Toxocara and toksakaris, causing toxocariasis and toxascaridosis. They are involved when talking of worms. They seem to be the same – yellowish white, like a worm, with sharp points. The sample length adult varies from 16 to 18 cm.

Most of his life, adult parasites pass in the upper small intestine. Both nematode species do not adhere to the intestinal wall. In order to stay in his favorite place, they are forced to move continuously against the contraction of the intestine. While dying, worms pass through the intestines and are simply digested by digestive enzymes. Therefore, it is almost impossible to see them in the stool.

What are the outward signs of worms in dogs and cats

separate fragments or whole segments of worms can be found in the stool or wool around the anus. Animals “rides” the bottom. The general condition worsens, there is a lack or an increase in appetite, difficulty swallowing or pain, hair loss, chronic cough. There may be alternating constipation and diarrhea, occasional vomiting.

Note that the symptoms of worm infection are often similar to the effects that occur in most infectious and noninfectious diseases, so for an accurate diagnosis, it is necessary to contact a veterinarian.

How to get rid of worms in animals

There are many different solutions. Albendazole is the most reliable of them all – pay attention to the type of animal that is giving the medicine. Before giving the preparation, the animal should be weighted. Carefully read the instructions on the site and always adhere to the dose!

Albendazole is designed for all types of worms, round and ribbonlike.

In severe cases of worm infection, anthelmintics should only be used under the supervision of a veterinarian.

High efficiency is achieved for the treatment of nematodes, tapeworms. The drug is used for both poly- and mono-invasions.

At the same time, too frequent and unjustifiable use of anthelmintics can damage the immune system and liver. Do not be swayed by frequent use.

Dosage:

Albendazole is used in veterinary medicine. The dosage is selected taking into account the type of animal and its weight:

for the animals

dogs and cats – 0.25 g / 8 kg;

cattle – 0.5 g / 50 kg;

small livestock – 0.5 g / 80 kg;

birds – 0.5 g / 50 kg;

pigs – 0.5 g / 40 kg;

horses – 0.5 g / 100 kg.

See detailed instructions on using albendazole for animals.

Contraindications

The medicine is not recommended if you are hypersensitive to its components. Do not take albendazole during pregnancy and lactation.

Between treatment cycles needed to support a space of at least two weeks, otherwise are possible undesirable consequences.

There are a large number of albendazole sellers on the pet market, one of the quality sellers is Homelab. Albendahelm 500 with active ingredient Albendazole 500. You can buy it and other quality veterinary medicine at Homelabvet.com.

analogs

Albendazole belongs to the group of benzimidazoles. Therefore, the main analogs for humans are mebendazole and thiabendazole. Other anthelmintic agents of this group (fenbendazole, oxfendazole) are only used in veterinary medicine as greater toxicity.

How often must worming cats

To prevent infection, anthelmintics are given from once to twice a year to once every 4 months, depending on the situation. A high risk of infection, for example, when feeding raw meat or offal, fish, eating garbage, or feces on the street – worming can be done once every 3 months.

It is necessary to carry out deworming before vaccination if the last preventive deworming was more than 4-6 months ago.

Can humans get worms cats

82 helminth species recorded in the animals, 32 can parasitize humans. Worms are very easily passed when a person’s hygiene standards are not respected. Cats and dogs are most often infected with toxocariasis, dipylidiasis, toxascaridosis, and hookworms. Three of the aforementioned types of worms are dangerous to humans.

To prevent infection, strictly follow the rules of personal hygiene, do not let animals lick on the face, be sure to wash your hands after contact with animals.

 

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Cat parasites

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Cat parasites

Even 30 years ago, according to veterinarians, in the USA about 90% of cats were constantly struck at once by several types of parasites. And even now, parasitic diseases are extremely common. If, for example, the owner removes his pet in the summer to the country, the risk of infection of the pet will increase significantly. In addition, there are parasites that live on the body of the animal constantly.
However, lately, veterinary pharmacology has made a big step forward, and the general availability of antiparasitic drugs has increased. Moreover, with adequate medical care, the majority of parasites today are much less dangerous than 30 years ago. But what they are? How does the owner recognize if his pet is infected? What to do in case of their appearance?

What types and types of parasites secrete today?

Most often, parasites are distinguished by their location. So, to external parasites (ectoparasites) include:

  •  Fleas. They live in the coat of the animal.
  •  Lice. Also found in cats fur.
  •  Ear mites (otomycosis). Live in the ears of the animal.
  •  Ixodic ticks. These parasites cat can bring, for example, with a walk.

Also, internal parasites that live in the cat’s gastrointestinal tract are isolated. Various helminths belong to this group: roundworms and tapeworms and flukes, among which nematodes and roundworms are the most common.

What can be dangerous parasites cats?

  1. Some types of parasites that are dangerous for cats can be dangerous for their owners: for example, some types of helminths,  fleas.
  2.  Parasites usually feed at the expense of their host: skin scales, secretions of the sebaceous glands, blood (like a flea or hookworm). This often causes pain and anxiety to the animal, and in severe cases they can cause anemia – anemia.
  3.  Many blood-sucking parasites are carriers of dangerous diseases that can pose a risk to the life and health of a pet. These include, for example, infectious anemia of cats, which is tolerated by both ticks and fleas.
  4.  Fleas can provoke various skin inflammations, and helminths significantly reduce the immune status of cats. 
  5.  A sick pet can infect other animals living in your home.

How to diagnose parasites at home?

The correct answer is no way. The nuances of the diagnosis of parasites are too many, and some of them are too subtle to detect them, especially at first. Therefore, the cat should undergo regular medical examinations in your veterinary clinic, and you should not forget to monitor its health indicators.

Pay close attention to the skin and coat, the state of the mucous membranes, and the quality of your pet’s stool, and if any abnormalities appear, consult a doctor who will be able to correctly diagnose the disease and, if necessary, prescribe treatment.

What symptoms are alarming?

The pet’s treatment is prescribed by a doctor, but you must be vigilant to distinguish signs of possible illness in time.

If you notice any of the symptoms listed below, immediately consult a veterinary specialist:

  •   Helminths or their eggs in the feces or cat vomit;
  •   Fleas, lice, or ticks in cat hair;
  •   Strong scratching and traumatic hair loss;
  •   General lethargy and discomfort of a pet;
  •   Pale mucous, change in color, and texture of feces.

How to prevent infection by parasites?

The comprehensive protection of cats from parasites is to conduct regular preventive measures.

So, to combat internal parasites, it is recommended to use combined anthelmintic agents that effectively protect animals from most worms. As a rule, broad-spectrum preparations in the form of tablets or suspensions in prophylactic doses are used once a quarter.

Prevention of the appearance of external parasites in cats consists mainly of external treatments in the warm season – from May to October. There are a large number of antiparasitic drugs on the pet market, one of them is Helmintazole 200 Pet with active ingredient fenbendazole 200. You can buy it and other quality veterinary medicine at Homelabvet.com.

Nowadays, simple to use and quite effective drops, which are applied to the pet’s skin in the area of ​​the withers, are the most popular. To form stable protection against the entire spectrum of external parasites, it is enough to process the animal once every 3-4 weeks.

For the final determination of drugs for your cat and the frequency of their use, you should consult with your veterinarian.