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Eye care for cats and dogs. Veterinarian advice. Treatment

Ciflodex eye and  ear drops for dogs and cats

Eye care for cats and dogs

Homelab shares tips for caring for the eyes of cats and dogs: what you need to know about prevention, how to recognize anxiety symptoms and what diseases are most common.

eye hygiene in cats
cat eye infection treatment

Eye hygiene in cats

As a rule, the eyes of newborn kittens open after 2-3 weeks. For everyone, this process occurs in different ways: sometimes one eye can open and only then the other, and sometimes both at once. If by the third week your eyes have not opened, you need to start rinsing them with a solution of tea or ordinary boiled water to soften the eyelids. Adult cats are able to take care of their hygiene on their own: their daily self-care includes washing their faces and eyes. But no one is immune from external factors – injuries, dust, worms, heredity and household chemicals. Therefore, you must immediately take your pet to the doctor if you notice alarming symptoms. These include antibiotics for cat eye infection:

purulent discharge; prolonged lacrimation; hard crusts in the corners of the eyes; fur on the face with traces of tears; red or white inner side of the eyelid; visible third eyelid; cloudy or discolored eyes; closed eye (or both).

Some cat breeds are more prone to eye diseases than others. Head of the Center for Veterinary Ophthalmology Alex M. notes: “Champions” in eye diseases are brachycephalic (“flat-faced”) breeds – Persian cats, exotic cats, British, as well as hairless, Siamese and Maine Coons. However, there is probably not a single breed that I would not treat ”. To prevent the development of the disease, regular prevention is necessary.

“Prevention is primarily about adhering to the vaccination schedule, treatments for ecto- and endoparasites,” says John S, an ophthalmologist at the PETMEDS veterinary clinic. – As for the eyes, it is necessary to sanitize (rinse) as the discharge appears – with light, smooth movements, remove the accumulated discharge using a cotton pad moistened with either filtered water or specialized ophthalmic lotions.

eye hygiene in dogs
eye hygiene in dogs

Eye hygiene in dogs

According to ophthalmologist-microsurgeon Alex M, among dogs, eye problems are most common in Pekingese, Pugs, Yorkshire Terriers, Sharpei and Cocker Spaniels. Many eye diseases in animals are transmitted at the genetic level: for example, more than 150 dog breeds suffer from hereditary cataracts, and about 20 breeds suffer from progressive retinal atrophy. Some diseases are very difficult to recognize at an early stage. For example, glaucoma or cataracts are difficult to detect without medical diagnosis, but conjunctivitis or keratitis will become noticeable with eye discharge and redness.

However, the symptoms of diseases may look the same. In such cases, it is very difficult to make a diagnosis on your own, and the wrong treatment can damage the pet. “Let’s take the seemingly simplest situation: a dog’s eye turned red. Everything seems to be very simple. Redness is the first sign of conjunctivitis. The owners begin to drip antibiotics on their own without a doctor’s examination, as a result, the animal may become permanently blind. Why? Because it was an acute attack of glaucoma, which is also accompanied by redness of the eyeball. Such cases occur in my practice every week, ”says David M.

Do’s and don’ts for injuries (eye drops for dogs; what eye drops can I use on my dog?)

In case of eye injury, you should immediately consult a specialist. In this case, you will need to consult an ophthalmologist. If there is no way to come to the doctor, you can try to provide first aid yourself.

“First wash your hands, wipe them with an alcohol wipe. Plant the affected eye towards the light. Using your index finger and thumb, gently pull apart your eyelids and examine the damaged eye. If there is a foreign surface in the eye, it can be removed with a gauze swab. After removing the foreign body, rinse the eye with antibiotic drops – Prodex or “Ciflodex” will do, — (dog eye drops over the counter with a composition of dexamethasone and ciprofloxacin)  recommends David M.

In case of injuries, in no case:

Allowing the animal to rub its eye is irritating. In addition, the animal can further damage the eye and cause infection. If your pet scratches its eye, wear a protective collar over it. They are sold at all pet stores. If there is no pet store nearby, cut the collar out of a 5-liter drinking water bottle (if you have a small animal) or from a plastic bucket (if you have a large one). The collar should be slightly longer than the animal’s muzzle.

Try to forcefully open the injured eye. The risk of additional injury is very high.

Apply on your own eye drops and ointments containing prednisolone or dexamethasone. Without a doctor’s prescription, they can be dangerous and worsen the condition.

Top Eye Problems In Canine
Top Eye Problems In Canine

The most common eye diseases in pets

conjunctivitis  (conjunctivitis eye dogs)

Inflammation of the inner lining of the eyelid, the symptoms of which are redness, swelling of the eye and purulent discharge. There are many possible causes of the disease: infections, parasites, irritating drugs, bruises, foreign bodies, lime dust, smoke, ultraviolet and X-rays, and mold fungi needs cat eye antibiotic.

keratitis

Eye Inflammation, the main symptom is that the eye begins to grow cloudy and watery. The animal’s behavior changes, the pet worries about constant pain, and photophobia develops. Causes: Infection or injury.

Inversion and eversion of the eyelid

Signs: The eyelashes and edge of the eyelid are wet and turned in or turned out. There is lacrimation and redness of the conjunctiva. Because of this, keratoconjunctivitis (simultaneous inflammation of the cornea and conjunctiva of the eye) can develop. Causes: trauma, chemical and thermal burns, microbes, viruses and some parasites.

Сataract (cataract dogs)

A cataract is a clouding of the lens. Its symptoms are not obvious, since the processes take place inside the eye for quite a long time. The lens becomes white or bluish. Cataracts are common in older cats and dogs. In the last stages of the disease, the animal does not see well with the affected eye. Causes: previous infections, as well as inflammation and trauma.

cataract surgery for dogs 

To date, the only effective way to treat cataracts is surgery, which results in the replacement of a clouded lens with an intraocular lens (IOL) or an artificial lens.

Glaucoma

Eye disease caused by increased intraocular pressure. The main symptom is a constant or periodic increase in pressure inside the eye. Symptoms include corneal opacity and decreased sensitivity. In this case, the eye is greatly enlarged and hardened. Causes: complications of deep purulent keratitis, hemorrhage or dislocation of the lens.

Alex M also notes that eyeball injuries are common in animals. This is not necessarily related to fighting – due to their curiosity, dogs and cats often like to dig in the grass during the warmer months. This can be dangerous: according to the ophthalmologist, pets often injure their eyes on the skeleton of cut grass or thorns. The stems are infected with pathogenic microflora, which destroys the surface of the cornea at the site of injury. The infection quickly spreads throughout the eye. In some cases (for example, with panophthalmitis), the eye cannot always be saved.

Homelab recommends that the owner see an ophthalmologist if a disease is detected. This will allow you to help your pet as soon as possible, as well as reduce the risk of relapses and complications. The ophthalmologist advises, for prevention purposes, to bring your pet for an examination once a year until the pet is 7 years old. After 7 years, more often – once every 6 months.

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What is fenbendazole? How does fenbendazole work?

panacur fenbendazole

The best broad spectrum benzimidazole anthelmintic for Dogs, for Cats, for Fish and Chickens is Fenbendazole

Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits, and seals.

In this article, we would like to tell you a little about such an affordable and at the same time very effective veterinary remedy as Fenbendezole. To begin with, we would like to say a few words about its pharmacological properties.

Pharmacological (biological) properties and effects of Fenbendazole (Panacur)

panacur fenbendazole
Panacur C (fenbendazole)

 

Fenbendezole is an anthelmintic of the benzimidazole group. Fenbendazole (5-phenyl-thio-2-benzimidazole carbamate) has a wide spectrum of nematodocidal and cestodocidal action, is active against adult forms, larvae and eggs of gastrointestinal and lung nematodes, as well as cestodes that are parasitic in animals.

The mechanism of action of fenbendazole is the destruction of microtubules in the intestinal cells of helminths and disruption of energy processes, which leads to the death of parasites.

When administered orally, fenbendazole is easily absorbed in the intestine and distributed in the organs and tissues of the animal; it is excreted from the body in unchanged form and as metabolites, mainly with bile and partially with urine, in lactating animals also with milk.

In the recommended doses, it is very well tolerated by animals without any side effects.

Indications for use of the drug FENBENDAZOLE

This drug is prescribed to young cattle, sheep, goats, foals, piglets, dogs and cats for therapeutic and preventive purposes.:

— nematodes;

— cestodoses.

Application procedure

Fenbendezole is administered to animals according to the type and dosage of Fenbendazole (powder, tablets, capsules …), in the following doses. Young cattle with moniesiasis – 150 mg per 15 kg of animal weight; with dictyocaulosis, haemonhoses, bunostomiasis, esophagostomiasis, nematodyrosis, ostertagiasis, habertiosis, cooperiosis and strongyloidiasis – 150 mg per 20 kg of animal weight.

Sheep and goats with moniesiosis – 150 mg per 15 kg of animal weight; with dictyocaulosis, hemonchosis, bunostomosis, esophagostomosis, nematodirosis, ostertagiosis, trichostrongyloidosis, habertiosis, cooperiosis, strongyloidosis – 150 mg per 30 kg of animal weight.

Foals with paraskaridosis and strongylatosis – 150 mg per 15 kg of animal weight.

Piglets with ascariasis, esophagostomosis, strongyloidosis, trichocephalosis, metastrongyloidosis – 150 mg per 30 kg of animal weight.

Adult dogs and cats with toxocarosis, toxascaridosis, hookworm, uncinariosis, dipilidiosis, teniidosis – 150 mg per 1.5 kg of animal weight.

Puppies and kittens (aged over 3 weeks) with toxocarosis, toxascaridosis, hookworm, uncinariosis, dipilidiosis and teniidosis 1 time/day for 3 consecutive days in a single dose of 150 mg per 3 kg of animal weight.

Special diets and laxatives are not required before deworming.

Side effect

Side effects and complications when using fenbendazole in accordance with the indications and dosage regimen, as a rule, are not observed.

With increased individual sensitivity of the animal to fenbendazole and the appearance of allergic reactions, the use of the drug is discontinued.

Symptoms of overdose in animals were not detected.

Contraindications to the use of the drug FENBENDAZOLE

— individual hypersensitivity of the animal to fenbendazole.

Do not use the drug:

— emaciated and sick with infectious diseases animals;

— puppies and kittens younger than 3 weeks of age.

Special instructions and personal prevention measures

Slaughter of animals for meat is allowed no earlier than 14 days after deworming. In case of forced slaughter before the deadline, the meat can be used as food for carnivores or for the production of meat and bone meal.

Milk from dairy animals should not be used for food purposes within 3 days after deworming. Milk obtained earlier than the deadline can be used after heat treatment in animal feed.

It is forbidden to smoke drink or eat while working with the medicine. At the end of work, wash your hands with warm water and soap.

If you decide to deworm your animal with Fenbendezole, you can safely recommend the following products, but please note that fenebendazole exists in different forms (powder, tablets, capsules, liquid), first decide in what form it will be more convenient for you to give it. From myself, I would like to make a small note that Fenbendezole in the form of capsules is very convenient to use, except for the smallest animals.

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Things You Should Know About Canine and Feline Arthritis

Dog Arthritis

Arthritis

is an infamous problem among dogs. Many vets and dog owners struggle for years, trying to control the lameness, soreness, and reduced activity level associated with canine osteoarthritis. But in recent years veterinarians have made significant strides towards understanding more about osteoarthritis in cats – mainly from the standpoint of simply recognizing that it does happen and that it can cause significant pain and discomfort in our feline friends.

Because cats are so good at hiding their medical problems from us, it’s important that cat owners understand how to recognize potential problems before they become serious. Read on to learn about the symptoms associated with arthritis, and some strategies for successfully dealing with this problem.

Just how big of a problem is this?

One study looked at the x-rays of 100 cats that were randomly selected and between ages 6 months and 20 years. The study found signs of osteoarthritis in 91% of cats in their front and rear leg joints. It found evidence of arthritis in the spine of 55% of these cats. The study also found that the incidence of arthritis increased dramatically as cats aged.

What’s even more interesting is that arthritis is often what we consider an “incidental” finding on the x-rays of cats, meaning that the vets weren’t even taking the x-rays because they suspected a problem in that location. That fact alone should really drive home the point that many, many cats are living with this problem, and very few of them are telling us about it.

Most of the time when people say “arthritis”, they mean “osteoarthritis”. But there are other types, and it’s worth a couple of minutes of our time to understand exactly what we mean when we diagnose the problem.

Osteoarthritis is the most common type of arthritis in both dogs and cats. It occurs when the cartilage that covers the surface of joints wears away, eventually causing bone to contact bone and exposing the exquisitely sensitive pain receptors in these areas. The body tries really hard to fix the problem by creating new cartilage, but unfortunately cartilage doesn’t regenerate very well, and the “new” surface is often bumpy and uneven.

Why does the cartilage gets worn in the first place? Most of the time it’s due to either previous joint damage, such as might occur if a cat is hit by a car or falls from a high place, or due to a birth defect that resulted in improper formation of the joint. We’re really just starting to understand that hip dysplasia, previously thought to be almost exclusively a problem of large dogs, is pretty common in our feline friends as well.

Other types of arthritis include septic arthritis, due to infection in the bloodstream, and immune-mediated arthritis, such as what we see in people who have rheumatoid arthritis. Both of these kinds of arthritis do occur in cats, but much less often than osteoarthritis.

My cat doesn’t have arthritis. I’ve never even seen him limping.

Another fascinating finding about feline arthritis is that cats with the disease typically don’t look anything like dogs with the disease. We’re used to seeing “gimpy” old dogs, that hobble around due to osteoarthritis, so it makes sense that we’d expect the same from cats. However, we’re commonly reminded in vet school that cats aren’t small dogs, and this is just one of the many ways that they’re different. Cats with arthritis typically don’t display signs of lameness.

So how are you supposed to get the hint that your cat might have osteoarthritis? The signs are subtle, but if you pay attention you’ll see changes in your cat that will prompt you to go to the vet, who can do a thorough orthopedic exam and hopefully zero in on areas of pain. Signs of arthritis in cats include sudden aggression towards people or other animals in the house (especially in cats that used to be happy and peaceful), difficulty jumping, loss of interest in surroundings, decreased activity levels, avoiding the litter box (even when previously trained well), vocalizing, and decreased grooming (especially overgrown claws).

The most interesting symptom to me in this list is the development of litter box problems. Failure to use the litter box is the number one reason that cats are relinquished to shelters in the U.S. How truly sad to think that many of these cats might really be painful, and have problems getting into and out of the box, or with squatting. This is one of the reasons that fixing litter box problems always starts with a complete medical workup.

But my cat’s not old!

Unfortunately, arthritis is a disease that can happen to young cats as well as old cats. This is especially true in cats that have previously experienced trauma. Even if the injury was repaired, the potential for in congruencies in a previously normal joint is there. When the joint isn’t properly fitted together, there’s room for laxity, and this laxity creates the cartilage erosion that leads to osteoarthritis.

Can’t I just give my cat some aspirin?

аспирин

No, please don’t! We counsel owners frequently about whether to treat cats at home for pain. While it can be dangerous to use over-the-counter human pain relievers in dogs, it’s absolutely critical that drugs like aspirin, Tylenol, and Advil NOT be given to cats. Aspirin and Advil (and other drugs like them such as Motrin) create severe gastrointestinal problems as well as kidney failure. Tylenol produces a severe and life-threatening problem called Heinz body anemia in cats.

Unfortunately, cats do not do well with most of the pain relievers that we easily use to treat arthritis in dogs. However, with close observation, they can tolerate some drugs well and provide significant relief and improvement in clinical signs. The opioid drug buprenorphine can be administered orally to cats and has excellent analgesic effects. The downside is that it tends to be expensive with prolonged use and can cause constipation. Tramadol is a synthetic opioid that has long been used in humans and may provide more cost-effective relief for cats. And gabapentin helps many cats feel better. VetExpert Arthrovet Capsules and Canina Petvital Arthro Tablets are very effective for cats and dogs. You can buy these drugs from the Homelabvet Online Store.

Currently, Metacam appears to be the only veterinary drug that is both effective and generally safe for long-term use in cats for inflammatory pain associated with arthritis. Because it can also cause gastrointestinal problems as well as kidney failure, cats taking this drug should be closely monitored with repeated lab tests to look for signs that the drug may be causing side effects.

What else can I do to help relieve pain associated with arthritis?

Start by changing your environment. Place food and water where you do not need to jump. Use ramps and stairs to help cats climb and get off furniture. Create trash bins you don’t have to jump into by purchasing plastic storage bins and cutting out a “door” on the side. Groom your cat regularly, especially in areas that are difficult for a cat with arthritis to reach. And make sure your cat has a warm and comfortable sleeping environment.

Supplements such as fish oil and glucosamine can also help. It is important to use products that are reliably manufactured and formulated for cats. There are also several high-quality diets available for cats with osteoarthritis. And since obesity exacerbates the clinical signs of arthritis, losing weight on your cat is likely to significantly improve well-being.

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Ivermectin (Iverhelm) treatment is a ”real killer of parasites”

Ivermectin for sale online price vet pharmacy

Ivermectin (Iverhelm)

Characteristics of the substance Ivermectin
Refers to avermectins.

Pharmacology
Pharmacological action – local anti-inflammatory.
Pharmacodynamics

It has an anti-inflammatory effect by suppressing the production of inflammatory cytokines induced by lipopolysaccharides. The anti-inflammatory properties of ivermectin have been observed in animal models of skin inflammatory processes. Ivermectin also causes the death of parasites, mainly through selective binding and high affinity for glutamate-regulated chlorine channels found in the nerve and muscle cells of invertebrates. The mechanism of action of ivermectin in the treatment of inflammatory skin lesions in rosacea is not fully understood, but it may be associated with both anti-inflammatory effects and the ability to cause the death of Demodex mites, which, in turn, can be a factor causing skin inflammation.

Pharmacokinetics

Suction. The absorption of ivermectin was assessed in a clinical study involving adult patients with severe papulopustular rosacea, using the maximum tolerated dose. In equilibrium (after 2 weeks of treatment), the highest mean (± standard deviation) plasma concentrations of ivermectin were observed within (10 ± 8) h after application (Cmax – (2.1 ± 1) ng / ml, range – 0 , 7-4 ng / ml), and the highest mean (± standard deviation) AUC0-24 was (36 ± 16) ng · h / ml, range – 14-75 ng · h / ml). Systemic exposure to ivermectin reached a plateau by the end of the second week of treatment under steady state conditions. With longer treatment in phase III studies, the systemic exposure to ivermectin remained the same as after 2 weeks of treatment. Under Css conditions, the levels of systemic exposure of ivermectin (AUC0-24 (36 ± 16) ng · h / ml) were lower than after a single oral intake of 6 mg ivermectin in healthy volunteers (AUC0-24 (134 ± 66) ng · h / ml) …

Distribution. An in vitro study has shown that the binding of ivermectin to blood plasma proteins (mainly albumin) is more than 99%. No significant binding of ivermectin to erythrocytes was observed.

Metabolism. In in vitro studies using human liver microsomes and recombinant CYP450 enzymes, it has been noted that ivermectin is metabolized primarily by CYP3A4.

In vitro studies have shown that ivermectin does not inhibit the isoenzymes CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP4A11 or CYP2E1. Ivermectin does not induce the expression of isoenzymes CYP1A2, CYP2B6, CYP2C9 or CYP3A4) in cultured human hepatocytes. The two main metabolites of ivermectin (3′-O-demethylivermectin and 4a-hydroxyivermectin) were identified in a clinical pharmacokinetic study using the maximum allowable dose of this agent and were studied in phase II clinical trials. Like the parent compound, the metabolites reached equilibrium by the end of the second weeks of treatment, no signs of accumulation were observed in the period up to 12 weeks In addition, the systemic exposure of metabolites (assessed using Cmax and AUC), obtained at steady state, was much lower than for ivermectin after oral administration.

Excretion. The final T1 / 2 averaged 6 days (approximately 145 hours, range 92-238 hours) in patients who applied ivermectin to the skin 1 time per day for 28 days in a clinical pharmacokinetic study using the maximum allowable dose. Excretion from the body depends on the degree of absorption after topical application. The pharmacokinetics of ivermectin have not been studied in patients with impaired liver and kidney function.

Application of the substance Ivermectin
Inflammatory skin lesions in rosacea (papulopustular form) in adult patients.

Contraindications
Hypersensitivity; pregnancy; period of breastfeeding; age up to 18 years (safety and efficacy for this age category has not been studied).

Restrictions on use
Liver dysfunction.

Application during pregnancy and lactation
Data on the use of ivermectin in pregnant women are limited. Reproductive toxicity studies when taking ivermectin orally have shown that it has teratogenic potential in rats and rabbits, however, due to the low systemic exposure when applied externally at the recommended dosage, the risk of fetotoxicity in humans is low. The use of ivermectin during pregnancy is contraindicated.

After oral administration, low concentrations of ivermectin are excreted into breast milk. When applied topically, the release of ivermectin into breast milk has not been studied. Pharmacokinetic and toxicological data from animal studies also indicate the excretion of ivermectin in breast milk. The risk to the nursing infant cannot be excluded. If necessary, the use of ivermectin should stop breastfeeding.

Side effects of the substance Ivermectin


The most common adverse reactions, such as burning sensation, skin irritation, itching and dry skin, were noted in less than 1% of patients treated with ivermectin in clinical trials.

On the part of the skin and subcutaneous tissues: often (≥1 / 10) – burning sensation of the skin; infrequently (≥1 / 1000, <1/100) – skin irritation, itching, dry skin; frequency unknown – contact dermatitis, allergic reactions.

Typically, these reactions are mild to moderate and usually diminish with continued therapy.

There were no significant differences in the safety profile among patients aged 18 to 65 years and older.

Interaction
Studies on the interaction of ivermectin with other drugs have not been conducted. Concomitant use with other agents for external and systemic use for the treatment of rosacea has not been studied. Caution should be exercised when used simultaneously with strong inhibitors of CYP3A4, since the concentration of ivermectin in the blood plasma can increase significantly.

Overdose
There have been no reported cases of ivermectin overdose.

Symptoms: In case of accidental or significant exposure of a person to unknown amounts of veterinary forms of ivermectin (ingestion, inhalation, parenteral administration or contact with the body surface), skin rash, facial edema, eyelid edema, headache, dizziness, asthenia, nausea, vomiting, etc. diarrhea. Other reported adverse reactions include seizures, ataxia, shortness of breath, abdominal pain, paresthesia, urticaria, and contact dermatitis.

Treatment: in case of accidental ingestion, symptomatic therapy is carried out, including parenteral administration of fluids and electrolytes, respiratory support (providing oxygen and, if necessary, mechanical ventilation) and vasopressors (in the presence of a pronounced decrease in blood pressure). To prevent the absorption of ingested ivermectin, provoking vomiting and / or urgent gastric lavage followed by the use of laxatives and other measures to eliminate intoxication may be indicated.

Route of administration
Outwardly.

Precautions for the substance Ivermectin
The components of the finished dosage form of ivermectin can cause local skin reactions (eg contact dermatitis), allergic reactions (including delayed-type reactions), skin irritation.

Wash your hands after use.

After drying, you can apply cosmetics.

Influence on the ability to drive vehicles and work with mechanisms. Ivermectin does not affect or slightly affects the ability to drive vehicles and operate machinery.

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FISH parasites killer | Fish Zole | Metronidazole 250 mg

metronidazole 500mg for dogs for fish flagyl for fish for sale price

Metronidazole for fish – fish parasites killer

Metronidazole is an antibiotic that exerts a bactericidal action on gram-positive and some gram-negative bacteria in fish. Useful to help control some common bacterial diseases in fish such as Aeromonas, Pseudomonas, and Mycobacterial (Gill diseases and Chondrococcus). Effective against anaerobic bacteria, a bacteria that only grows where there is no oxygen. Also used to control parasitic diseases such as Cryptocaryon irritans, Ichthyophthirius multifiliis, and Hexamita.


Features:

  • For fish only
  • Exerts a bactericidal action on gram-positive and some gram-negative bacteria in fish
  • Useful to help control some common bacterial diseases in fish
  • Easy to use tablets

Item Specifications:

Strength:

250mg

Ingredients:
Metronidazole Directions of Use:
Add one tablet (250mg) into aquarium for each 10 gallons of water to be treated. Repeat in 24 hours. It is suggested that a partial water change be made between treatments. While duration of treatment depends on type and severity of infection, it is recommended that extended medication baths continue for a minimum of 5 days and not for more than 10 days. Discontinue treatment if no improvement is noted within 5 days. To remove harmless yellow color, change 20% of water and use charcoal filter until clear.

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Parasites in Fish ? Bendazole (Fenbendazole) ? Panacur

Parasites in Fish

Most of the drugs listed below are anthelmintic (antihelminthic) drugs. These are chemical preparations that effectively destroy various parasitic helminths (“worms”). With regard to fish parasites, this group includes trematodes, nematodes and cestodes (tapeworms). These medicines are given to the fish by mouth with food, although some are also effective in the form of baths. Anthelmintics used for bath treatments have been shown to be effective against non-helminth ectoparasites such as Argulus or Argulus carp lice. If the dosage for a specific drug is not listed, you should consult your veterinarian.

Many of the anthelmintic drugs used to treat fish are also used in humans, so in some countries they can only be obtained through a veterinarian. Other such agents, for example trichlorfon, are organophosphorus compounds. These are extremely toxic chemicals, and their sale is highly regulated.

It is important to remember that the life cycle of ectoparasites is quite complex and includes many stages. Some stages are resistant to chemicals, others are more vulnerable. Since resistant stages can remain viable for a long time, re-treatment is often necessary to completely eradicate the parasites.

In addition to the chemicals listed below, there are a number of specialty aquarium medicines on the market for some of the larger ectoparasites. They should be used in accordance with the manufacturer’s instructions. It is very important to follow through with the recommended course of treatment. Allow enough time for the eggs or cysts that are resistant to chemicals to hatch into larvae.

Bendazole Fenbendazole (Panacur)


Fenbendazole is used primarily to treat worms in horses. In addition, it is useful in the fight against fish nematodes such as Camallanus. It can be purchased as an equine anthelmintic. In the aquarium hobby, this medicine is used as a powder or granule, not a dough. A three-week course of treatment is carried out by the method of long baths with a dose of 2 – 3 mg/liter, and on the 7th and 14th days, the procedure is repeated.

Fenbendazole (PANACUR) aquarium dosage

Also be aware that fenbendazole seems to soak into the porous live rock and be absorbed indefinitely. I know one hobbyist who transferred a small piece of live rock that had been treated with fenbendazole (Panacur) months earlier into a reef tank, where it killed the resident starfish and Astrea snails. So enough of the medication may be retained within treated live rock to impact sensitive animals months after the fenbendazole was administered. Don’t treat live rock intended for reef systems with fenbendazole (Panacur)!

At the lower dosage recommended for nursery tanks (1/16 tsp. Per 10 gallons), fenbendazole normally does not harm cleaner shrimp and decorative shrimp. With the exception of Astrids (Astrea), Coit and Worden have found it does not usually affect the types of snails typically used as cleanup crews (e.g., Nassarius, Ceriths, and Nerites). It will kill starfish but copepods, hermit crabs, and shrimp are normally not affected.

Macroalgae such as the feathery or long-bladed varieties of Caulerpa or Hawaiian Ogo (Gracilaria) are not harmed by exposure to fenbendazole at even triple the normal dose. In fact, if you will be using Caulerpa in your nursery tanks to provide hitching posts for the fry and serve as a form of natural filtration, it’s a very wise precaution indeed to treat them with a regimen of fenbendazole beforehand.

fenbendazole panacur suspension safe guard dog pharmacyFenbendazole 10% fish bendazole Liquid SUSPENSION PANACUR

So fenbendazole (FBZ) or Panacur is primarily useful for ridding bare-bottomed nursery tanks and dwarf seahorses setups of hydroids and Aiptasia anemones, ridding Caulerpa and other macroalge of hydroids or Aiptasia before its goes into the aquarium, and cleansing live rock of bristle worms, hydroids, and Aiptasia rock anemones before it is introduced to the aquarium.  If you are serious about raising seahorse fry, fenbendazole is must-have med for keeping your nurseries hydroid free.

It can also be used to eradicate bristle worms, hydroids, an Aiptasia from an established aquarium if it does not house sensitive animals such as live corals and gorgonians, starfish, Astrea snails, or tubeworms and other desirable worms that may be harmed by FBZ, providing you monitor the ammonia levels closely and are prepared to deal with the ammonia spike that may result from the sudden death of the worm population.

Caution: For aquarium and ornamental fish only. not for human use. keep out of the reach of children. keep the container tightly closed and in a cool dry place. not to be given to fish intended for food use.

 
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Catosal Bayer is a unique stimulant of the metabolism

Catosal bayer online shop price

Catosal Bayer

Currently, the market for veterinary drugs is well filled and it is difficult to find a drug that has no analogs. Catosal is a rare exception to this rule. It is truly one of a kind drug. Its uniqueness is Butafosfan – an active substance discovered by Bayer specialists in 1926 (!) And still has no analogs.

Catosal bayer vitamina b12 homelab price

The preparation contains two active ingredients: butaphosphamide and cyanocobalamin. Butafosfan is an organic phosphorus compound. Phosphorus compounds affect many assimilation processes in the body. Phosphorus plays a leading role in the activity of the central nervous system. The metabolism of phosphorus compounds is closely related to the metabolism, in particular fats and proteins. Phosphorus plays an important role in the processes occurring in the membranes of intracellular systems and muscles (including the heart). The role of organic compounds of phosphorus is also significant in the energy supply of vital processes. Macroergic phosphorus compounds – ATP and creatine phosphate – accumulate energy, which can then be used for mechanical (muscle contraction), electrical (nerve impulse conduction), chemical (biosynthesis of various compounds) and electrochemical (active transport of substances through membranes) work. With a lot of positive effects on the state of systems and organs, organic phosphorus compounds do not accumulate in the body and do not have side effects characteristic of stimulants and inorganic phosphorus. Butafosfan has the following effects on the animal’s body:

  • improves the utilization of glucose in the blood, which helps to stimulate energy metabolism;
  • accelerates metabolic processes by stimulating the ADP_ATP cycle;
  • activates all functions of the liver;
  • increases the nonspecific resistance of the organism;
  • stimulates smooth muscles and increases its motor activity;
  • restores tired heart muscle;
  • stimulates the formation of bone tissue;
  • normalizes the level of cortisol in the blood;
  • stimulates protein synthesis, accelerating the growth and development of the animal, as well as the reparative properties of organs and tissues.

Vitamin B12 – CATOSAL (METABOL) Bayer

The properties and complex of effects of cyanocobalamin are well known. And yet, for a clearer understanding of specialists about the complex of Catosal effects, we highlight the following:

  • stimulation of hematopoiesis
  • participation in the formation of creatine (a source of energy for muscle tissue)
  • participation in the biosynthesis of acetylcholine, which affects the state of the nervous system
  • participation in fat metabolism and metabolism of carboxylic acids
  • normalization of the process of assimilation of food
  • biosynthesis of methionine.

Indications for use: The complex of active ingredients of the drug allows its use in various fields of veterinary medicine and makes it practically irreplaceable in many treatment regimens.

Catosal is successfully used in the following cases:

  • With metabolic disorders of different etiology
  • With a decrease in the productivity and performance of animals;
  • For the prevention and treatment of infertility and postpartum complications;
  • In the treatment of secondary anemias
  • To recover animals after stress
  • To stimulate the growth of young animals
  • To normalize liver function
  • As an auxiliary therapy for intoxication, viral and bacterial infections, damage to organs and systems.

The use of Catosal in the treatment of various diseases accelerates the recovery of the animal, improves rehabilitation after illness, and reduces the risk of relapse. Catosal also helps to quickly restore the animal in the postoperative period: to reduce the likelihood of complications after anesthesia and infections.

Dosage and application features: Catosal is applied intramuscularly, subcutaneously, and intravenously in the following doses:

Dogs: 2.5 – 5 ml (average 1.0 to 3.0 ml per 10 kg of animal weight)
Cats and fur animals: 0.5-2.5 ml (on average, 0.5 to 2 ml per 5 kg of animal weight)
Horses: 10-25 ml (average 10-15 ml per 100 kg of body weight)
The product can also be used for birds. It is possible to inject the drug or drink it with drinking water at a dosage of 0.1-0.3 ml per 100 ml of water (for ornamental birds).
The instruction on the use of the drug provides for one or two administrations of Catosal at intervals of a week, however, as a result of the active use of Catosal by veterinarians, there are many different schemes for its use. Summarizing them, we can formulate the following general recommendations regarding the frequency of application of Catosal.

  1. One or two applications with an interval of two to seven days: to prevent or neutralize the effects of stress on the body; to increase the likelihood of fertilization of an egg in females, to improve the quality of sperm in males; to increase the activity and endurance of animals before exhibitions and competitions, to improve appetite, as well as to restore performance after prolonged or increased stress, in the postoperative period.

Case history 2. Pug dog, female, 3.5 years old. The animal was observed and treated in the clinic from the age of three months. At 3 months, the dog was treated for demodicosis. The anamnesis of life also: chronic cystitis after the first mating; a small number of puppies, difficult childbirth. Before the second mating of the animal, it was necessary to ensure the prevention of cystitis, as well as to increase the likelihood of giving birth to a larger number of puppies compared to the first mating.

Was proposed the drug “Catosal” subcutaneously in a dose of 3.0 ml every other day. Treatment course: 10 injections. No recurrence of cystitis was observed after mating. The dog independently (without medical assistance) gave birth to 5 puppies. During feeding, the bitch only slightly lost her condition. All puppies were active and viable, in the condition they corresponded to standard parameters.

Case history 3. Dog breed boxer, bitch. History of a difficult childbirth, 9 puppies, all different in weight (from 350 to 600 grams). After childbirth, there was an inflammation of the uterus, a lack of milk, and was treated with antibiotics. The puppies received artificial nutrition. As a result, all puppies developed severe dysbiosis, bloating and soreness of the intestines, and, as a result, growth retardation and skin rashes were observed over the entire surface of the body.

The following treatment was proposed: Lactobifadol and Catosal – subcutaneously (from 5 days of age) at a dose of 1.0 ml to puppies, and at a dose of 5.0 ml to a female, subcutaneously daily for 10 days. A positive trend was noted after 10 days. However, since both the bitch and the puppies still looked unsatisfactory, a second course of treatment with Catosal was carried out 14 days later at a dose of 2.0 ml to the puppies, and at a dose of 5.0 ml to the bitch subcutaneously daily for 10 days. By the date of vaccination (2 months), all the puppies leveled off according to the parametric data and weight, the skin rash disappeared, after weaning the puppies, the bitch quickly regained normal condition.

The drug Catosal was used in the clinic as an adjuvant in the complex treatment of other diseases, such as demodicosis, anemia (in this case, Catosal was prescribed as a rehabilitation agent after piroplasmosis and babesiosis), streptoderma, for skin diseases (including allergic ones), kidneys, heart, liver, pancreas, intestinal dysbiosis, after operations. The described clinical data indicate the multifaceted positive effect of Catosal on the animal organism and make it possible to recommend to veterinarians and breeders a wider use of this drug.

 

 
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ALIZIN Virbac Aglepristone. Reproduction in the Dogs and Cats

Alizin

ALIZIN Virbac Aglepristone ☞

Reproduction in the Dogs and Cats

PROGESTINS AND ANTIPROGESTINS
Progesterone (P4) is a natural steroid hormone secreted by the corpus luteum of the ovary. It acts by binding to the progesterone receptor (PR) and causes a variety of physiological effects such as the closure of the cervix at the end of estrus, the proliferation of the endometrium, regulation of fallopian tube motility and secretory activity as a precondition for fertilization and inhibition of myometrial contractility during pregnancy …

Antiprogestins (eg aglepristone, Alizin®, Virbac) have an antagonistic effect on progesterone, they bind to PR but prevent P4 from its biological action. Spontaneous contractions are possible due to the cancellation of the gestagen-induced blockage of contractions, the cervix opens, and therefore the uterus can empty. For successful treatment, a progesterone concentration of more than 1 ng/ml is required. Thus, antiprogestins can be used to terminate a pregnancy, treat pyometra, induce labor, and treat fibroadenomatosis in dogs and cats.

ABORTION

Termination of pregnancy may be necessary after unwanted mating, in case of pregnancy with one puppy or pregnancy-induced diseases in the female. Compared to previous drugs, the use of antiprogestins has only minor side effects. In addition, the efficacy rate is higher during the early termination period (days 0-22) and has an efficacy rate of 99-100%.

Usually, early termination of pregnancy leads to resorption of the embryo without obvious clinical signs. Due to the fact that the moment of mating is extremely individual, in order to avoid mating the female after treatment, it is advisable to inject the female after confirmation of cytological dysstruus based on the results of a vaginal smear.

You must enter 10 mg/kg over the next two days. The injection area under the skin must be massaged and, if the volume is more than 5 ml, the injection should be administered at different places. A third injection may be needed on day 7 if the ultrasound shows that the uterus is filling.

Aglepristone can also be used to terminate pregnancy in cats: the recommended dosage is 10-15 mg/kg, the injection protocol is the same as the injection protocol for dogs.

TREATMENT PIOMETERS

The conservative treatment for pyometra should be applied late in pregnancy or for aging females that are in poor condition. The risk of side effects after treatment with antiprogestins is much lower than after treatment with prostaglandins. Aglesterone is used alone or in combination with antibiotics; progesterone in a concentration above 1 ng/ml is required for successful treatment. For the treatment to be as effective as possible, an ultrasound scan must be performed regularly. In addition, ovarian pathologies such as cysts or tumors, glandular cystic hyperplasia of the endometrium should be ruled out before starting treatment.

Interestingly, treatment-related luteolysis shortens inerrestrus, which has been observed and verified in several studies. There is no statistical difference in the development of pyometra in females with or without the prior disease. By analogy with dogs, pyometra in cats is gestagen-dependent and once cystic endometrial hyperplasia has been ruled out, it can also be successfully treated with aglepristone according to the canine protocol.

INDUCTION OF LABOR

Induction of labor can result in premature, non-viable puppies and retained placenta. Use should be limited to therapeutic indications: maternal morbidity (toxicosis, eclampsia, preterm labor), the risk of pathologies due to fetomaternal imbalance, primary inertia of the uterus, and abnormally long pregnancy.

FIBROADENOMATOSIS

Fibroadenomatosis is a gestagen-induced, benign proliferation of mesenchymal and epithelial cells in the mammary gland of a young pregnant individual. It can also be caused by the use of exogenous progestins in cats, cats, and even male dogs. Aglepristone treatment is a successful alternative to sterilization and does not affect later pregnancies. The protocol for the treatment of induced fibroadenomatosis is 10 mg/kg subcutaneously on days 0.1 and 7. In the case of progestin-induced fibroadenomatosis, sequential injections may be required depending on the duration and effectiveness of the progestin and its half-life compared to natural progestins. It is important to inform the owner that treatment in pregnant cats will also induce abortion.

CONCLUSIONS

The antiprogestin aglepristone (Alizin, Virbac) is a new, highly effective, and well-tolerated drug for abortion, treatment of pyometra, induction of labor, and treatment of fibroadenomatosis in dogs and cats. The use of estrogens is now an obsolete treatment. For successful treatment, an accurate dosage and application interval according to the manufacturer’s instructions, as well as careful

ALIZIN Virbac buy ✅ online Shop Homelabvet

Alizine 30 mg/ml Aglepristone 10 ml

ALIZIN 30 MG/ML SOLUTION FOR INJECTION

Marketing-authorization holder :
Virbac – 1ère avenue – 2065 m – L.I.D. – 06516 Carros Cedex – France

NAME OF THE VETERINARY MEDICINAL PRODUCT

Alizin 30 mg/ml Solution for Injection

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENT(S)

Each 1 ml contains:
– active substance
aglepristone 30 mg

INDICATIONS

Pregnant females: induction of abortion up to 45 days after mating.

CONTRA-INDICATIONS

Do not use in dogs with impaired hepatic or renal function, in diabetic animals, or in dogs in poor health.

Do not use in dogs with either manifest or latent hypoadrenocorticism (Addison’s disease) or in dogs with a genetic predisposition to hypoadrenocorticism.

Do not use in dogs with known hypersensitivity to aglepristone or the product excipient.

ADVERSE REACTIONS

In females treated after 20 days of gestation, abortion is accompanied by the physiological signs of parturition: fetal expulsion, vaginal discharge, reduced appetite, restlessness, and mammary congestion. In infield trials, 3.4 % of dogs suffered from uterine infections. After induced abortion with the veterinary medicinal product, an early return to oestrus is frequently observed (oestrus – oestrus interval shortened by 1 to 3 months).

Side effects such as anorexia (25 %), excitation (23 %), depression (21 %), vomiting (2 %), and diarrhea (13 %) have been reported from field trials.

In infield trials, the administration of the veterinary medicinal product produced pain during and shortly after injection in 17 % of dogs and a local inflammatory reaction at the injection site in 23 % of dogs. The size and intensity of this reaction depended on the volume of the veterinary medicinal product which was administered. Oedema, skin thickening, local lymph-node enlargement, and ulceration may occur. All local reactions are reversible and will usually disappear within 28 days after injection.

In infield trials, administration of the veterinary medicinal product induced hematological/biochemical changes in 4.5 % of dogs. These changes were always transient and reversible. The modified hematological parameters were as follows: neutrophilia, neutropenia, thrombocytosis, hematocrit variation, lymphocytosis, lymphopenia.

The modified (elevated) biochemical parameters were as follows: urea, creatinine, chloride, potassium, sodium, ALT, ALP, AST.
In case of partial abortion or no abortion, repeat treatment may be recommended 10 days after treatment, between day 30 and day 45 after mating. Surgery should also be considered.

In rare cases, a hypersensitivity reaction has been/can be observed.

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What about Tylosin for dogs?

What about Tylosin for dogs?

Tylosin 500mg powder tylan for dogs

Tylosin-responsive diarrhea (TRD) is a syndrome that includes all cases in which tylosin antibiotic treatment has had a positive effect on treating dogs with intermittent or chronic diarrhea. Antibiotic treatment often leads to resolution of clinical gastrointestinal (GI) signs, and thus the term antibiotic-responsive diarrhea (ARD) was coined. Recently, trials have been published in which tylosin proved to be particularly effective in treating dogs with chronic or intermittent diarrhea, with the effect of tylosin differing from that of other antibiotics, thus indicating that the more newly established term TRD is more appropriate than ARD.

Tylosin antibiotic

Tylosin is a macrolid, bacteriostatic antibiotic that has activity against most Gram-positive and Gram-negative cocci, Gram-positive rods and Mycoplasma. However, the Gram-negative bacteria Escherichia coli and Salmonella spp. are intrinsically tylosin-resistant. Tylosin is used only in veterinary medicine, and its most common indications are treating pigs with diarrhea or poultry with chronic respiratory diseases. Tylosin has also been used as a feed additive in food animal production, and it has been shown to increase gain and feed efficiency, especially in pigs. Debate about the mechanisms underlying tylosin-mediated growth enhancement is ongoing.

Tylosin is usually used in powder form for pigs and poultry. In Finland and in some other countries, tylosin is also available in tablet form, facilitating its use in dogs.

Experiences of tylosin in treating diarrhea

Our experience with tylosin is derived from numerous studies with dogs suffering from exocrine pancreatic insufficiency (EPI).These studies have clearly shown that tylosin has a favorable effect as a supportive therapy on dogs with EPI.

In Finland, tylosin has for years been the most common drug in the treatment of unspecific intermittent or chronic diarrhea in dogs. Anecdotal reports by veterinarians and dog owners reveal that many dogs with diarrhea respond well and quickly to tylosin treatment, generally within a few days of initiation of treatment. When treatment is discontinued, however, diarrhea reappears in many dogs within a matter of weeks or months. Some dogs need a treatment over very long period. Even so, the effect of controlling diarrheal signs does not appear to diminish with time, and thus there is no need to increase the dosage of the medication. No apparent tylosin-associated adverse effects have been reported.

TRD can affect dogs from all breeds and ages but is most often seen in middle-aged, large-breed dogs. The diarrea signs appear often as intermittent but progressivly become more frequent and end as persistent diarrhea. Abnormal loose fecal consistency is the predominant sign. The majority of the owners describe their dogs’ feces as watery and/or mucoid indicating that TRD affects both the small and large bowel. Increased frequency of borborygmus and flatulence are also typically seen. Vomiting is occasionally seen during the diarrheal outbreaks.

In dogs with TRD the blood parameters are usually normal. Also the abnormal findings in diagnostic imaging studies and histological examination of intestinal biopsies, are only mild or completely absent.

Clinical studies with tylosin

Only a few studies on treating diarrheal signs in dogs with tylosin have been published. Van Kruiningen, (1976) reported more than 30 years ago that tylosin had a good effect in treatment of unspecific canine diarrhea. Recently, our study group performed two clinical trials to obtain more information on TRD. The first study included 14 adult pet dogs of 12 different breeds. Each dog’s diet remained unchanged throughout the study. The dogs had shown chronic or intermittent diarrheal signs for a period of more than one year. Diarrhea had been successfully treated with tylosin for at least six months, and the treatment had been discontinued at least twice but the signs had always occured. When the study commenced, all dogs had been on tylosin for at least one month and were otherwise healthy. Thereafter, tylosin was discontinued and the dogs were monitored for a period of up to one month to determine whether signs of diarrhea would reappear, as suggested by the clinical history. Diarrhea reappeared in 12/14 dogs (85.7%) within 30 days. During the treatment trial diarrhea ceased with tylosin in all dogs within three days and in most dogs within 24 hours. In contrast, prednisone did not completely resolve diarrheal signs, and the probiotic Lactobacillus rhamnosus GG did not prevent the relapse of diarrhea in any of the dogs.

In the second study in an experimental dog colony, seven beagles showed signs of chronic diarrhea for at least one month. The dogs were treated with tylosin for ten days. During the treatment period the feces became significantly firmer, although they remained unacceptably loose. When the treatment was discontinued, diarrhea reappeared within three weeks. Treatment with other antibiotics (metronidazole, trimethoprim-sulfadiazine, or doxycycline) or with prednisone had almost no effect on fecal consistency, the feces remaining abnormally loose in all dogs. The diet was then changed for a ten-day period from a highly digestible moist pet food to a dry food developed for normal adult dogs. The feces again became significantly firmer, although they remained loose in some dogs. The dry food period was then extended to three months, but the fecal consistency continued to fluctuate from ideal to diarrhea. Since the consistency was not satisfactory, the dogs were treated a second time with tylosin for ten days. The feces then became normal in consistency and remained so throughout the entire three-month follow-up time. The study revealed that in the experimental dogs with chronic diarrhea the fecal consistency became significantly firmer both with tylosin treatment and with dietary modification. Neither of the treatments alone was sufficient to obtain ideal fecal consistency, but when the dogs were treated simultaneously with both regimes, permanent ideal fecal consistency was attained. The study thus indicated that tylosin and feeding regimes have synergic effects.

Pathophysiology

The etiology of TRD remains obscure. Since tylosin is an antimicrobial agent, it has been speculated that some pathogenic bacteria are likely responsible for the diarrheal signs. Based on negative culture results and ELISA tests, we have excluded such common enteropathogenic bacteria as Clostridium perfringens, Clostridium difficle, Salmonella spp., Campylobacter spp. , and Yersinia spp. as causative factors for the diarrheal signs occurring in TRD. Less well-defined species causing diarrhea in dogs, such as Plesiomonas shigelloides, Lawsoni intracellularis, and Brachyspira spp., have also been excluded.

Our ongoing studies have revealed that administration of tylosin leads to significant but transient changes in the composition of the small intestinal microflora. The results support the hypothesis that tylosin promotes the growth of beneficial commensal bacteria, while suppressing deleterious bacteria.

Besides antibacterial properties, tylosin may possess anti-inflammatory properties, contributing to its effectiveness in treating canine diarrhea. The mode of action must differ, however, from the immunomodulatory effect of prednisone because prednisone treatment did not completely resolve diarrheal signs in the same dogs that responded to tylosin.

Diagnostic protocol for dogs with chronic diarrhea

The diagnostic protocol used for dogs with chronic diarrhea by the Faculty of Veterinary Medicine, University of Helsinki, is represented in Figure 1. In patients with chronic diarrhea, every effort should be made to achieve a diagnosis to enable a specific therapy. Unfortunately, this is not always possible in which case empirical therapeutic trials are used in the workup of these patients. There are conflicting opinions about how long an empirical therapy should be attempted. We recommend ten days if a dog has chronic diarrhea or if the interval between intermittent diarrheal episodes is only a few days. If signs of diarrhea disappear or are relieved during this period, the treatment should be continued another 2-6 weeks. When the interval between episodes of intermittent diarrhea is long, i.e. more than one week, the length of the empirical treatment period should be prolonged. The workup protocol displayed in Figure 1 for patients with chronic or intermittent diarrhea is applicable to most veterinary practices. It is also useful regardless of whether the clinical signs are typical of large- or small-intestine disease. The prevalence of diseases that can simultaneously affect the small and large intestines is high.

The initial evaluation (A) comprises obtaining a thorough case history (A1), conducting a physical examination (A2), and taking the basic laboratory tests, including a complete blood count, a serum chemistry profile, and measurement of serum concentrations of trypsin-like immunoreactivity (TLI) (A3). According to the initial examination, the patients are then divided into two groups. The first group includes patients showing clinical abnormalities in addition to diarrhea (Group B), while the second group shows no obvious abnormalities other than diarrhea (Group C).
Patients with obvious abnormalities (B) suffering from systemic disorders with secondary diarrhea (B1a), such as hepatic failure, renal failure, hypoadrenocorticism, and EPI (B1b), should be identified before starting trial therapies. Also if hypoproteinemia (B1c), melena and/or anemia (B1d), or abnormal palpation findings (B1e) are found, the reason for these abnormalities should be examined.
Dogs with diarrhea but no other abnormalities (C) are treated orally with fenbendazol 50 mg/kg for three days (C1) to rule out endoparasites as the causative factor for GI signs.

Food is probably the most common cause of diarrhea (C2), and adverse food reaction should always be excluded before empirical treatment trials with different drugs are initiated. Opinions vary widely about how the diet should be changed for a dietary treatment trial. Unfortunately, current recommendations are largely based on anecdotal evidence rather than on controlled trials. The most common recommendation is to use a diet with novel protein and carbohydrate sources, with the former restricted to a single animal source.

If modifying the feeding regime fails to produce a satisfactory fecal consistency, the next step is to treat the dog with tylosin 25 mg/kg BW q24h (C3). Dogs responding to tylosin treatment will usually do so within 3-5 days, and diarrhea will remain absent as long as treatment continues. In many dogs, diarrhea will reappear within some weeks upon discontinuation of treatment. If diarrheal signs reappear, the dog owner should change the dog’s diet once again to make sure that the feeding regime is not involved in the etiology of the signs. If diarrheal signs continue, tylosin treatment is re-initiated. The effect of tylosin does not appear to diminish even in dogs that have been treated for years. The dose of tylosin for long-term use should be tapered to the lowest possible dose that controls clinical signs. Many dogs need only half of the recommended dose.

Although no adverse effects during tylosin treatment have been reported, efforts should be made to reduce the use of tylosin. This is because our recently conducted studies have indicated that tylosin causes wide resistance to antibiotics in the intestine (unpublished results). Certain probiotic lactic acid bacteria (LAB) have been shown to be effective in the prevention and treatment of a variety of diarrheal disorders in humans and in experimental mouse models. Hopefully in the future a probiotic LAB can be used instead of tylosin to treat or prevent chronic diarrhea in dogs with TRD.

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Mastitis: causes, symptoms, prevention, and treatment

cow mastitis

Mastitis: causes, symptoms, prevention, and treatment

Cause

Mastitis is the inflammation of the mammary gland and udder tissue.

It usually occurs as an immune response to bacterial invasion of the teat canal by variety of bacterial sources present on the farm (commonly through bedding or contaminated teat dips), and can also occur as a result of chemical, mechanical, or thermal injury to the cow’s udder.

Mastitis is a multifactoral disease, closely related to the production system and environment that cows are kept in. Mastitis risk factors or disease determinants can be classified into three groups: host, pathogen and environmental determinants.

Symptoms

Subclinical: Few symptoms of subclinical mastitis appear, although it is present in most dairy herds. 

Somatic cell counts measure milk quality and can be used as an indicator of mastitis prevalence. 

Clinical mastitis: The most obvious symptoms of clinical mastitis in the udder are swelling, heat, hardness, redness or pain. 

Milk takes on a watery appearance, flakes, clots or pus is often present. 

A reduction in milk yields, increases in body temperature, lack of appetite, and a reduction in mobility due to the pain of a swollen udder are also common signs. 

Treatment

NSAID are widely used for the treatment of acute mastitis. Aspirin, flunixin meglumine, flurbiprofen, carprofen, ibuprofen, and ketoprofen have been studied as treatments for experimental coliform mastitis or endotoxin-induced mastitis. Orally administered aspirin should be used with caution in acute coliform mastitis because it may lead to severe rumen atony.

Prevention

  1. Hygienic teat management: which includes good housing management, effective teat preparation and disinfection for good milk hygiene, teat health and disease control.
  2. Prompt identification and treatment of clinical mastitis cases: including the use of the most appropriate treatment for the symptoms.
  3. Dry cow management and therapy: where cows are dried off abruptly and teats are cleaned scrupulously before dry cow antibiotics are administered, including the use of teat-end sealants if appropriate.
  4. Culling chronically affected cows: cows that become impossible to cure and represent a reservoir of infection for the whole herd.
  5. Regular testing and maintenance of the milking machine: with regular, recommended teatcup liner replacement and milking machine servicing and attention paid to items which must be checked on a daily, weekly or monthly basis.
  6. Good record keeping: of all aspects of mastitis treatment, dry cow therapy, milking machine servicing, Somatic Cell Counts and Bactoscan results, and clinical mastitis cases.

Diagnostics

It’s important to identify the pathogen causing the mastitis infection because different categories of pathogens require different mastitis management strategies. Without taking the time to determine a diagnosis, there is no way to know if a given antibiotic will work. However, once you know the pathogen, a dairy farmer can work with his or her veterinarian to develop a mastitis control program that fits your specific operation.

Consider your diagnostic options based on the needs of your dairy farm.

Overview of Testing Methods

Test Identification of mastitic milk Identification of pathogen Fast Reliability Test location Milk sample type
California Mastitis Test Farm Fresh milk
Somatic cell count Lab Fresh milk
ELISA Lab Fresh, Frozen, Preserved
Bacterial culture Lab Fresh
Multiplex PCR ✓✓ Lab Fresh, Frozen, Preserved
Test Principle
California Mastitis Test Detergent lyses white blood cells (leucocytes) in milk sample, resulting in viscosity of the fluid. This is a measure for severity of infection.
Somatic Cell Count Counting of leucocytes in a milk sample, either under a microscope or using automated cell counting systems (flow cytometry).
ELISA Detects antibodies instead of pathogen; infection may no longer be active.
Bacterial culture Milk sample is streaked on culture plates. Viable pathogens form colonies that are counted.
Multiplex PCR Amplification and detection of nucleic acid of mastitis-causing pathogens. Screening for multiple pathogens in one run. Indicates active infection. Pathogens do not need to be viable.

Submitting a clean milk sample to the laboratory is critical to a successful pathogen diagnosis. Follow these steps:

  1. Clean the udder from visible dirt
  2. Prevent kicking
  3. Wash your hands
  4. Clean the teat end with 3 clean swabs dipped in 70% alcohol disinfectant
    a. If the teat end is in poor condition,     more cleaning may be needed
  5. Open the milk tube corn and keep it clean in your palm
  6. Milk the sample keeping the tube in horizontal position
  7. Close the cork immediately
  8. Add markings like cow number, quarter and date on the tube
  9. Important: only one quarter to one tube